abstract：:Simultaneous measurements of left and right scrotal, and axillary skin temperatures were recorded in 58 consecutive adolescents (mean age 14.4 years) with a grade II-III left sided varicocele, and nine control adolescents without genital pathology (mean age 15.7 years). Left and right testicular volumes were determine...

journal_title：Advances in experimental medicine and biology

authors： Salisz JA,Kass EJ,Steinert BW

更新日期：1991-01-01 00:00:00

abstract：:We have studied the relationship between the in vivo aging process of the human red cell (RBC) and its main function, the transport of O2 from the lungs to the tissues. This study included several approaches. First, we observed that the affinity for O2 in young RBCs was lower than in old RBCs (p less than 0.0005) due ...

journal_title：Advances in experimental medicine and biology

authors： Samaja M,Rovida E,Motterlini R,Tarantola M

更新日期：1991-01-01 00:00:00

abstract：:Xenogeneic immunization of freshly-prepared human glioma extracts into goats has yielded a polyclonal antiserum, which after multiple absorptions specifically identifies antigenic entities only in glioma extracts, and not in appropriate controls, both by radioimmunoassays (RIAs) and Western immunoblots. The results fr...

journal_title：Advances in experimental medicine and biology

authors： Fischer DK,Matsuda M,Shaban F,Narayan RK,Atassi MZ

更新日期：1991-01-01 00:00:00

abstract：:The development of secretory IgA was followed in saliva of 263 children from birth to age 5, and in cross sectional studies of Australian school children and Papua New Guinea highland children from birth to age 5. Salivary IgA first appeared after the first week of life, peaking at 6 weeks, and falling again at 12 wee...

journal_title：Advances in experimental medicine and biology

authors： Cripps AW,Gleeson M,Clancy RL

更新日期：1991-01-01 00:00:00

abstract：:The mutational basis of APRT deficiency was studied in non-Japanese and Japanese patients. Fifteen different mutations have been identified altogether. Of these 4 were common, 6 were located in exon 3, and two at the exon 4-intron 4 junction. The common mutations were a missense mutation in exon 3 (asp65----val) and a...

journal_title：Advances in experimental medicine and biology

authors： Sahota A,Chen J,Stambrook PJ,Tischfield JA

更新日期：1991-01-01 00:00:00

abstract：:Phenobarbital, when administered prenatally in a small dose to animals, produced profound, and permanent effects on reproductive function in the offspring. Preliminary analysis of a unique cohort of adolescents who were exposed to phenobarbital in utero, suggests that long-term effects are also evident in the human. T...

journal_title：Advances in experimental medicine and biology

authors： Yaffe SJ,Dorn LD

更新日期：1991-01-01 00:00:00

abstract：:The formation of meat mutagens has been studied the last 10 years by carrying out modeling and meat cooking experiments in parallel. During this time, the list of meat mutagens has been growing, and continues to grow. The meat mutagens are usually produced in the crust of animal foods during frying, broiling, and baki...

journal_title：Advances in experimental medicine and biology

authors： Jägerstad M,Skog K

更新日期：1991-01-01 00:00:00

abstract：:We review here the covalent photo-binding induced by visible light between the essential amino acid tryptophan and the vitamin riboflavin. We discuss the biological implications of this photoadduct in relation to the hepatotoxic and cytotoxic effect associated to parenteral nutrients and to culture media exposed to th...

journal_title：Advances in experimental medicine and biology

authors： Silva E,Salim-Hanna M,Edwards AM,Becker MI,De Ioannes AE

更新日期：1991-01-01 00:00:00

abstract：:Cruciferous plant foods contain large quantities of secondary plant metabolites that have been shown to inhibit chemically induced carcinogenesis in animals. One mechanism by which these chemicals may inhibit carcinogenesis is through the induction of enzymes, such as cytochrome P-450-dependent monooxygenases, glutath...

journal_title：Advances in experimental medicine and biology

authors： Bradfield CA,Bjeldanes LF

更新日期：1991-01-01 00:00:00

abstract：:Many aspects of the structure of chymosin are quite unique even though structure comparisons indicate a high degree of structural homology with other eukaryotic aspartic proteinases. The structural homology is shown to be directly related to the sequence homology which varies from 30 to 60%. The recent structures of p...

journal_title：Advances in experimental medicine and biology

authors： Gilliland GL,Oliva MT,Dill J

更新日期：1991-01-01 00:00:00

abstract：:The mechanisms of NMDA-evoked transmitter release are still not clear. We demonstrate for the first time that NMDA-evoked acetylcholine release is depressed by endogenous liberated adenosine in functionally-hypoxic and non-hypoxic brain slices. Adenosine deaminase potentiates the release of 3H-acetylcholine from rat s...

journal_title：Advances in experimental medicine and biology

authors： Porsche E,Schwan T

更新日期：1991-01-01 00:00:00

abstract：:During the development of an amplification refractory mutation system (ARMS) assay for the detection of the Delta F508 mutation and corresponding normal locus in cystic fibrosis we discovered a family in which a further variant of the sequence exists. PCR amplification and direct sequencing of a region of exon 10 of t...

journal_title：Advances in experimental medicine and biology

authors： Schwarz M,Summers C,Heptinstall L,Newton C,Markham A,Super M

更新日期：1991-01-01 00:00:00

abstract：:Inhibition of human phospholipases A2 by cis-unsaturated fatty acids and their oxidative metabolites and/or polymers was studied using partially purified human phospholipases A2 and [1-14C]oleate labelled, autoclaved E. coli as substrate. As previously reported for other phospholipases A2, oleic and arachidonic acids ...

journal_title：Advances in experimental medicine and biology

authors： Franson R,Raghupathi R,Fry M,Saal J,Vishwanath B,Ghosh SS,Rosenthal MD

更新日期：1990-01-01 00:00:00

abstract：:In hypoxia, the tissue counter-current can thus, by virtue of the Bohr effect, increase tissue Po2 and thus tissue oxygenation. In hyperoxia, on the other hand, the counter-current system, acting as a diffusion shunt, can protect the tissue against adverse O2-toxic effects. It thus appears, that the counter-current sy...

journal_title：Advances in experimental medicine and biology

authors： Kobayashi H,Pelster B,Piiper J,Scheid P

更新日期：1990-01-01 00:00:00

abstract：:The protooncogene c-src is implicated in the development of the vertebrate nervous system. Its product pp60c-src is a tyrosine-specific protein kinase that is expressed in two phases of neural development. An activated form of the pp60c-src is highly enriched in the membrane of nerve growth cones and in the proximal n...

journal_title：Advances in experimental medicine and biology

authors： Maness PF,Shores CG,Ignelzi M

更新日期：1990-01-01 00:00:00

abstract：:ATP stimulates arachidonic acid release and prostaglandin biosynthesis (most likely via phospholipase A2 (PLA2) activation) and phospholipase C (PLC) activation in cultured rabbit coronary microvessel endothelial cells. Pertussis toxin pretreatment inhibits ATP stimulated prostaglandin release, but not ATP stimulated ...

journal_title：Advances in experimental medicine and biology

authors： Gerritsen ME,Mannix RJ

更新日期：1990-01-01 00:00:00

abstract：:The effects of a single nutrient deficiency on immune function is now most extensively characterized using the dietary zinc deficient murine model. Deficiencies in zinc have rapid adverse effects on host defenses of humans and rodents. This impaired defense seems to be, in part, the result of a reduction in number of ...

journal_title：Advances in experimental medicine and biology

authors： Cook-Mills JM,Wirth JJ,Fraker PJ

更新日期：1990-01-01 00:00:00

abstract：:Total dietary fiber (TDF) values for cereal grains, fruits, vegetables, processed foods, and purified or semi-purified dietary fiber products were determined by a new method using 8M urea and enzymes (urea enzymatic dialysis, UED, method). The results are compared with the official AOAC procedure. Soluble and insolubl...

journal_title：Advances in experimental medicine and biology

authors： Jeraci JL,Lewis BA,Robertson JB,Van Soest PJ

更新日期：1990-01-01 00:00:00

abstract：:We have identified a phosphoprotein phosphatase which dephosphorylates efficiently the NC protein of coronavirus JHM. The activity was found in L-2 murine fibroblasts, Wistar Furth rat neonatal brain extracts, Wistar Furth rat oligodendrocyte primary cells and in Roc-1 cells, an oligodendrocytic hybrid cell line. In b...

journal_title：Advances in experimental medicine and biology

authors： Mohandas DV,Dales S

更新日期：1990-01-01 00:00:00

abstract：:During 1980 to 1983, 40 patients with advanced or locally recurrent breast cancer were treated with the thermo-radiotherapy. Ten of these were primary cases and 30 recurrent. In 23 patients who had 2 to 3 lesions. Altogether there were 64 lesions treated. Combined thermo-radiotherapy was applied to the bigger lesions ...

journal_title：Advances in experimental medicine and biology

authors： Li RY,Lin SY,Zhang TZ

更新日期：1990-01-01 00:00:00

abstract：:After some notions on the mechanisms of action of radio-waves on solid tumours, the treatise illustrates the results achieved in the first 125 cases of malignant tumours treated with this method, its results are definitely encouraging, even in cases apparently with no hope. It also describes briefly the histologic mod...

journal_title：Advances in experimental medicine and biology

authors： Bazzocchi G,Spadoni F,Zambelli M,Camporesi A,Bazzocchi S,Saragoni A

更新日期：1990-01-01 00:00:00

abstract：:It has long been known that endogenous pyrogen, released as a result of injection of typhoid vaccine or in response to infection, produces fever and increases ACTH secretion. Recent studies have indicated that endogenous pyrogen is, at least in part, IL-1. This monokine has now been shown to activate the release of AC...

journal_title：Advances in experimental medicine and biology

authors： McCann SM,Rettori V,Milenkovic L,Jurcovicová J,González MC

更新日期：1990-01-01 00:00:00

abstract：:Brain malignancy, either primary or metastatic, in general is associated with a very poor outcome in spite of the best therapy modern medicine has to offer. The multimodality approach appears to offer the best chance of achieving our goal of improved survival (quality and quantity) and ultimately cure. Hyperthermia, t...

journal_title：Advances in experimental medicine and biology

authors： Page RC,Ricca GF,Dohan FC Jr

更新日期：1990-01-01 00:00:00

abstract：:The role of prolactin and of estradiol and progesterone in the control of the biosynthetic and secretory activity of TIDA neurons has been investigated in the following animal models: young female rats, aged female rats, and young male rats. The indices of TIDA neuronal function employed were a) mass of TH in neurites...

journal_title：Advances in experimental medicine and biology

authors： Porter JC,Kedzierski W,Aguila-Mansilla N,Jorquera BA,González HA

更新日期：1990-01-01 00:00:00

abstract：:Ammonia is generated from a large number of metabolically important reactions. Despite its central importance in whole body nitrogen homeostasis excess ammonia is neurotoxic and its concentration must be kept low. Ammonia generated in most extrahepatic tissues is detoxified by incorporation into glutamine (amide). Thi...

journal_title：Advances in experimental medicine and biology

authors： Cooper AJ

更新日期：1990-01-01 00:00:00

abstract：:Sprouting has been studied extensively using morphological markers, but relatively little is known regarding the molecular and biochemical events which underlie the sprouting response. Moreover, due to the lack of suitable markers, it has been difficult to examine changes in the major hippocampal pathways in animal le...

journal_title：Advances in experimental medicine and biology

authors： Geddes JW,Wilson MC,Miller FD,Cotman CW

更新日期：1990-01-01 00:00:00

abstract：:Fibers are broadly classified as soluble and insoluble based on their physical or analytical properties. Two human studies have been carried out in this laboratory utilizing soluble gums. The first compared a low fiber diet to the diet with an average of 19.5 g of added fiber per day from cellulose, an insoluble fiber...

journal_title：Advances in experimental medicine and biology

authors： Behall KM

更新日期：1990-01-01 00:00:00

abstract：:The process of insulin release evoked by D-glucose and other nutrient secretagogues is triggered by an increase in cytosolic Ca2+ activity. However, some other insulinotropic agents may stimulate insulin release at a close-to-basal concentration of cytosolic ionized calcium. The control of cytosolic Ca2+ concentration...

journal_title：Advances in experimental medicine and biology

authors： Malaisse WJ,Blachier F,Pochet R,Manuel y Keenoy B,Sener A

更新日期：1990-01-01 00:00:00

abstract：:The role of fibrin in the generation of new blood vessels was examined in this study. Using a wound chamber model, we investigated the sequential interactions between endothelial cells and the extracellular matrix during angiogenesis. Silicone tubes 5 mm long and 1.4 mm in internal diameter were sutured to the cut end...

journal_title：Advances in experimental medicine and biology

authors： Liu HM,Wang DL,Liu CY

更新日期：1990-01-01 00:00:00

abstract：:In summary, despite the many uncertainties regarding mode of action, these results have established that the soluble dietary fibre from oats, mainly (1----3)(1----4)-beta-D-glucan, is physiologically active in a fashion similar to guar gum. Extraction processes reduce the molecular size of the beta-glucan relative to ...

journal_title：Advances in experimental medicine and biology

authors： Wood PJ

更新日期：1990-01-01 00:00:00

abstract：:The relationship between oxygen concentrations in arteries, cytosol, and mitochondria and high energy phosphate metabolism was studied in perfused rat hearts subjected to low and high workloads during gradual hypoxia. PCr, ATP, and Pi were measured by 31P-NMR. Myoglobin oxygenation and cytochrome aa3 oxidation were me...

journal_title：Advances in experimental medicine and biology

authors： Ito K,Nioka S,Chance B

更新日期：1990-01-01 00:00:00

abstract：:To evaluate interrelationships among the oxygenation, the energy status, and the development of necrosis in tumor microregions, oxygen tensions were measured with microelectrodes, and ATP distributions were determined with a quantitative imaging technique using multicellular spheroids as in vitro tumor models. The res...

journal_title：Advances in experimental medicine and biology

authors： Walenta S,Dötsch J,Bourrat-Flöck B,Mueller-Klieser W

更新日期：1990-01-01 00:00:00

abstract：:Fibrin is a major component of atherosclerotic plaques, and there may also be situations in which intravascular fibrin is formed in contact with the endothelium. The studies to be presented describe the distribution of fibrinogen/fibrin I, fibrin II, and fragments D and D-dimer in normal vessels and atherosclerotic pl...

journal_title：Advances in experimental medicine and biology

authors： Kaplan KL,Bini A,Fenoglio J Jr,Kudryk B

更新日期：1990-01-01 00:00:00

abstract：:The present study was performed in order to study the development of sinusoidal blood flow heterogeneity during stepwise bleeding and during prolonged hemorrhagic hypotension. Two methods have been applied: Hepatic surface oxygen tension was measured by a multi-gold-wire-cathode. Sinusoidal perfusion patterns were dem...

journal_title：Advances in experimental medicine and biology

authors： Schywalsky M,Metzger HP

更新日期：1990-01-01 00:00:00

abstract：:Effects of feeding supplements of calcium, magnesium, manganese, selenium and potassium on dietary copper bioavailability of humans were investigated. Results indicated that the calcium supplements depressed fecal copper losses and improved body copper retention as did potassium supplements. Magnesium and selenium sup...

journal_title：Advances in experimental medicine and biology

authors： Kies C,Harms JM

更新日期：1989-01-01 00:00:00

abstract：:To investigate whether altered renal medullary prostaglandin (PG) synthesis is involved in the development of hypertension in spontaneously hypertensive rats (SHR), we compared the capacity of PGE2 synthesis in cultured renal papillary collecting tubule cells from young (4-week-old) and aged (16-week-old) SHR and cont...

journal_title：Advances in experimental medicine and biology

authors： Sato M,Abe K,Takeuchi K,Yasujima M,Hiwatari M,Omata K,Kasai Y,Kudo K,Kanazawa M,Yoshida K

更新日期：1989-01-01 00:00:00

abstract：:Erythrocyte phosphoribosylpyrophosphate availability for adenine was measured by silicon oil method previously described. The homozygotes of Japanese type APRT deficiency (n = 6, from 4 families) showed 4.3 +/- 2.7% (mean +/- standard deviation) of adenine PRPP availability and the heterozygotes (n = 5) showed 86.0 +/...

journal_title：Advances in experimental medicine and biology

authors： Takeuchi F,Kamatani N,Nishida Y,Miyamoto T

更新日期：1989-01-01 00:00:00

abstract：:In summary, we can come to a number of meaningful conclusions regarding chronic exposure to hypobaric hypoxia in rats (refer to Figure 1). First, despite an increased hematocrit, and thus increased oxygen carrying capacity, regional cerebral blood flow is elevated after 4 weeks of chronic hypobaric hypoxia. This eleva...

journal_title：Advances in experimental medicine and biology

authors： LaManna JC,McCracken KA,Strohl KP

更新日期：1989-01-01 00:00:00

abstract：:Effects of DMSO on heme synthesis and enzymes of the heme biosynthetic pathway were examined in human HepG2 hepatoma cells. HepG2 cells contain measurable levels of ALA synthase and ALA dehydratase, and their levels are increased after treatment of cells with DMSO. DMSO treatment also led to increases in heme content ...

journal_title：Advances in experimental medicine and biology

authors： Sassa S,Iwasa F,Galbraith R

更新日期：1989-01-01 00:00:00

abstract：:Erythropoietin producing cells were identified in the murine hypoxic kidney by in situ hybridization. The positive cells were peritubular cells, most likely endothelial cells of the cortex and outer medulla. Glomerular and tubular cells were not labelled. In three patients with renal adenocarcinomas associated with po...

journal_title：Advances in experimental medicine and biology

authors： Lacombe C,Da Silva JL,Bruneval P,Salzmann JL,Casadevall N,Camilleri JP,Bariety J,Varet B,Tambourin P

更新日期：1989-01-01 00:00:00